CJC-1295 Without DAC (Modified GRF 1-29) — GHRH Analogue Research Peptide

CJC-1295 Without DAC, commonly known as Modified GRF (1-29) or Mod GRF (1-29), is a synthetic 29-amino acid analogue of Growth Hormone-Releasing Hormone (GHRH). Through four targeted amino acid substitutions, the peptide exhibits enhanced resistance to enzymatic degradation while maintaining affinity for the GHRH receptor, making it a widely utilised compound in growth hormone axis research.

Supplied in high-purity lyophilised form, CJC-1295 Without DAC is frequently employed in laboratory and pre-clinical studies investigating pulsatile growth hormone release, endocrine signalling pathways, receptor pharmacology, and IGF-1 regulation.

What Is CJC-1295 Without DAC?

Modified GRF (1-29) is based on the biologically active 29-amino acid fragment of endogenous GHRH. The peptide incorporates four amino acid substitutions that significantly improve stability against enzymatic cleavage compared with native GRF (1-29), while preserving its ability to activate the GHRH receptor.

Unlike CJC-1295 with Drug Affinity Complex (DAC), which is designed for prolonged circulation through albumin binding, the no-DAC variant is characterised by a shorter duration of activity and is commonly selected for research models investigating discrete, pulsatile hormone signalling events.

As a result, CJC-1295 Without DAC has become one of the most widely studied GHRH analogues in laboratory research focused on growth hormone secretory dynamics and hypothalamic-pituitary signalling pathways.

Research Areas of Interest

• Growth Hormone-Releasing Hormone (GHRH) receptor research
• Growth hormone pulse dynamics studies
• Endocrine signalling pathway investigations
• IGF-1 regulation research
• Pituitary somatotroph biology
• Receptor pharmacology and signal transduction studies
• Growth hormone axis research models

Research Use Only

This product is supplied strictly for laboratory, analytical, and scientific research purposes only. It is not intended for human consumption, veterinary use, diagnosis, treatment, or prevention of any disease. All research should be conducted by appropriately qualified personnel within controlled laboratory environments.

For Research Use Only. Not for Human or Animal Consumption. Genesis Research Co.

Legal & Safety Information

This product is supplied strictly for laboratory research purposes only. It is not intended for human consumption, medical use, or any form of therapeutic application.

Genesis Research Co. does not promote or condone the use of this product outside of controlled research environments.

By purchasing, the customer acknowledges that they are responsible for ensuring compliance with all applicable laws and regulations within their jurisdiction.

Products are supplied in sealed vials and should be handled using appropriate laboratory protocols.